CASA – Spermolyzer

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Innovative SpermoLyzer microscope. Creative head with built-in digital camera & temperature controller.
Computer Assisted Semen Analysis System utilizes modern computer and advanced image processing techniques for clinical test of sperm motility, quality, morphology, vitality, DNA fragmentation, HOS and nuclear protein.

 

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Description

SpermoLyzer is the world’s most advanced, reliable and cost effective CASA. Fast, accurate and objective results for sperm analysis can be obtained for any Pathology and Andrology laboratories.

Features:

  • Touch smart interface
  • Soft/Hard copy Reports
  • Wi-Fi Tablet Support
  • Bar-Code Support
  • Integrated Sperm Chemistry Analyzer
  • Windows PC required
  • NO COST PER TEST FOR MOTILITY MODULE! Spermolyzer Metal Slide is a reusable single chamber to analyse Sperm Concentration and Quantitative assessment of Sperm Motility

Spermolyzer Software support:
* Sperm Dynamic Test.
* Sperm Morphology Test.
* DNA fragmentation Test.
* HOS Test.
* Sperm Vitality Test.

Computer Assisted Semen Analysis System utilizes modern computer and advanced image processing techniques for clinical test of sperm motility, quality, morphology, vitality, DNA fragmentation, HOS and nuclear protein. Based on the sperm test standards of the WHO 5th criteria (2010), the system can analyze the characteristic of sperm comprehensively through image processing of sperms. The system analyzes these values and generates accurate parameters to reflect sperms’ quality. The whole procedure is fast and provides several important information that are vital to present scientific basis for the male reproductive ability.

Standard Methods:
• Spermolyzer includes two standard methods ( Dynamic and Morphology)
• The analysis of the parameters is performed according to the recommendations given by The
world health organization (WHO) for the latest 5th edition for motility patterns & Morphometric
assessment of human semen.

1- Dynamic standard method :
• The method is designed to estimate the spermatozoa concentration and their motility in a native specimen.
• Determining spermatozoa concentration in ( million/ml)
• Measuring spermatozoa movement parameters and classify this movement to classes in accordance of WHO
recommendations .
• Measuring spermatozoa dynamic parameters ( VCL/VSL/VAP/MAD/ALH/BCF/LIN/WOB/STR)

2- Morphology standard method:
• The method is designed to determine the morphological parameters of Spermatozoa.
• The software calculate the ( TZI/SDI/MAI) according to the latest criteria Of the world health organization

3- Vitality test:
This test is important to determine if the non-motile spermatozoa are alive or dead. It should be assessed if a low percentage of sperm are progressively motile, e.g., 30 – 40%. The two most common methods of sperm vitality assessment:
• Eosin-nigrosin staining.
• The hypo-osmotic swelling test ( HOS).

4- Sperm DNA Fragmentation Test:
This test provides a reliable analysis of sperm DNA integrity that may help to identify men who are at risk of failing to initiate a healthy ongoing pregnancy. Information about sperm DNA integrity may help in the clinical diagnosis, management and treatment of male infertility and may be of prognostic value in assessing outcome of assisted conception treatment.

5- HOS:
The hypo-osmotic swelling test is based on the semi-permeability of the intact cell membrane, which causes
spermatozoa to “swell” under hypo-osmotic conditions. All the curled tail sperm are labeled as ‘Live Sperm’. The damaged / broken sperm membrane, allows fluids to pass across the membrane without any accumulation & hence there is No Cytoplasmic Swelling & the tail remains straight (No Curling). All these sperm are labeled as the Dead sperm.

6- Nuclear Protein Assay:
The mature chromatin contains around 85% Protamine & 15% Histone, where as immature chromatin contains more than 15% Histone.
Increased levels of persistent Histone in turn indicate a break in the development sequence of Histone – Transition Protein – Protamines, which significantly affect the DNA chain folding & vulnerability for increased DNA Fragmentation & this leads to decline in sperm fertilizing potential. Hence by evaluating Nucleoprotein assessment the diagnosis & prognosis of Male Infertility can be determined.

Creative Constant-Temperature Operation Desk
The operation desk makes provides a constant temperature of 37 during sperm testing during the whole test procedure. This in turn eliminates the influence of excessive low outside temperature on the tested sperm such as sperm velocity, sperm vitality etc.

Unique Virtual Grid Function
This function has realized the direct comparison of test results between human being and machine in the
system. If you wish to use manual counting there is no need to buy an expensive calibrated counting chamber,
it is all in your screen with the aid of virtual grid function.

Database:
• The in-built database enable the user to store, backup and restore any kind Of obtained information .
• The in-built database enable the user to generate historical report for any Patient.
• The in-built database is capable of helping researcher by generating many Statistics reports.

Other Features of Spermolyzer software:
• Spermolyzer software is able to automatically add appropriate comments according to the patient results.
• Spermolyzer software has the ability to generate accustom reports like Urine, Stool, CBC and Bone marrow with any captured image using the system digital camera and microscope.
•Spermolyzer software allows the user to record and print the manual test result of semen.

Ready to use Reagents; MiraStain and MeraKit series!

They are ready to use reagents which facilitate all Spermolyzer’s Sperm Function Tests Sperm Washing Media. The following kits and solutions are available:

SpermoLyzer (Smart CASA System): 
DNA fragmentation Test, Sperm Vitality Test, Sperm Dynamic Test, Sperm Morphology Test, HOS test.

Sperm Function Test Kit: 
Sperm Morphology Kit, Viscosity Reagnent Kit, Sperm Fructose Kit, Sperm Vitality Kit; Sperm pH Strips, Sperm HOS reagent Kit.

Andrology Solution Kit: 
Zink determination Kits, Nuclear protein assessment Kits, Antisperm antibody (IgG & IgA) Reagent Kits, Alpha–Glycosidase Kits, Leukocytes Confirmation Kits, DNA fragmentation reagent Kit.

Semen processing solutions: 
Non- Spermicidal semen collection pouch, IUI Catheter, Medium for sperm Swim down technique, Medium for sperm Swim up technique.

                                         SpermoLyzer               VS      Other model (SCA) CASA Comparison Table

ItemSpermoLyzerOther (SCA)
General viewSpermolyzer
Technology

Image analysis. Video images of the sperm cells are captured and analyzed by the software.

Automated results can be “corrected” manually as recommended by WHO hence the name CASA (Computer Aided Semen Analysis).

Multi algorithms are applied for maximum accuracy according to the sample concentration.

LIS integration capability.

Image analysis. Video images of the sperm cells are captured and analyzed by the software.

Automated results can be “corrected” manually as advised by WHO hence thename CASA(Computer Aided Semen Analysis).

User interfaceTouch screen for easy navigation.
Help and User manual.
Tablet support (Windows OS) for doctor review.
Complex user interface requires extensive training.
System navigationUser friendly and easy to use interface with touch screen technology.Navigation can be cumbersome
Sample size5 – 50 μl10 – 50 μl
Sample preparation

Variable dilution depending on sample quality. The user must decide how to prepare the sample. In cases of high concentrations, sample dilution must be undertaken to avoid measurement errors.

Multi algorithms are applied for maximum accuracy.

Variable dilution depending on sample quality. The user must decide how to prepare the sample. In cases of high concentrations, sample dilution must be undertaken to avoid measurement errors.

Multi algorithms are applied for maximum accuracy.

Sample loadingLoading the sample into a counting chamber (special and non-disposable slide).Loading the sample into a counting chamber (special and non- disposable slide).
CalibrationOne-time calibration.One-time calibration.
VisualizationHi-resolution digital camera.
Up to 120 frames/second.
Objective: x10, x20, x40 and x100
Hi-resolution digital camera.
Up to 60 frames/second.
PC interfaceAll in on PC touch screen connected to a Microscope with mounted camera.Microscope with mounted camera
PrintingPC printer.PC printer.
ArchivePC based.PC based.
ReportsUser customized reports including report header, footer and specified results.
Support for color reports.
Auto comment generation.
User customized reports including report header and specified results.
ResultsObjective and complete results for Motility, Morphology, Vitality and DNA Fragmentation.Objective and complete results for Motility, *Morphology,*Vitality and *DNA Fragmentation.
*Each module costs extra money!
AccuracyAs low as ONE sperm for centrifuged samples and as high (million/ml) as dilution can be applied. Not specified
Motility parameters

Count, PR, NP, IM, VAP, DAP,

VSL, VCL, VAP, LIN, BCF, ALH, WOB, MAD, STR and more along with detailed velocity charts.

Count, PR, NP, IM, VAP, DAP,

VSL, VCL, VAP, LIN, BCF, ALH, WOB, MAD, STR and more along with detailed velocity charts.

Morphology parametersNormal and abnormal forms with detailed results for all defects along with MAI, SDI and TZI parameters.
Reports are supported by slide images and selected sperms images for showing different defects of the provided sample.
Detailed results with images support in reports.
VitalityAvailable with no extra cost.Available for extra cost.
DNA fragmentationAvailable with no extra cost.Available for extra cost.
DatabaseAvailability of results and media for all samples.Availability of results and media for all samples.
StatisticsVery sophisticated stats are available for researchers.Not specified.
LimitationsOptimum image/video capture is required.– Optimum image/video capture is required.
– Very low concentrated samples are not measured correctly.
– No ability to exclude debris and non-sperm cells
Other featuresAutomatic comment. Bar codeprinting/reading. Multi language interface. Auto database backup.
Option for burning a CD (soft copy) for the patient (media and PDF reports).
Multi user account and privileges.

–   Multi language interface.

–   Auto database backup.